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Early infiltration of p40IL12+CCR7+CD11b+cells is critical for fibrosis development
2016
Immunity, Inflammation and Disease
Macrophages are heterogeneous and thus can be correlated with distinct tissue outcomes after injury. Conflicting data have indicated that the M2related phenotype directly triggers fibrosis. Conversely, we hypothesize here that the inflammatory milieu provided by early infiltration of pro-inflammatory macrophages dictates tissue scarring after injury. Methods and Results: We first determined that tissue-localized macrophages exhibit a pro-inflammatory phenotype (p40IL12 þ CCR7 þ CD11b þ ) during
doi:10.1002/iid3.114
pmid:27621813
pmcid:PMC5004285
fatcat:vvtbpve6ijcktbrrkmpuuadacy