Propofol is a common intravenous (IV) anesthetic drug, used for induction of general anesthesia. Pain during bolus injection is a major drawback of propofol. Different methods of propofol formulations and drugs have been used to decrease pain on propofol injection (POPI), but still it remains an unresolved problem. It is assumed that IV administration of diluted lignocaine in a large volume before propofol injection could be more effective in prevention of both immediate and delayed types of

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... n associated with propofol injection than the most commonly used method of mixing lignocaine with propofol (20 mg lignocaine added to the 20 ml propofol). Objectives: The aim of this study was to compare the effect of lignocaine used in a large volume for prevention of propofol injection pain. Materials and methods: Eighty adult patients undergoing general anesthesia for elective ENT surgery were included in this study. Patients were classified into two groups, Group A (study group), in which 20 mg lignocaine diluted into a total volume of 20 ml using normal saline was given IV after venous occlusion for with BP cuff followed by propofol injection. In group B (control group), 20 mg lignocaine was mixed with propofol and given to the patient as commonly used. Results: This study showed statistically significant reduction in pain on propofol injection (POPI) in the study group compared to control group. Conclusion: Lignocaine when used diluted with normal saline in large volume after venous occlusion has significantly reduced propofo linjection pain in adults.