A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2019; you can also visit the original URL.
The file type is
The major histocompatibility complex (MHC) region encodes human leukocyte antigen (HLA) genes and is the most complex region in the human genome. The extensive polymorphic nature of the HLA hinders accurate localization and functional assessment of disease risk loci within this region. Using targeted capture sequencing and constructing individualized genomes for transcriptome alignment, we identified 908 novel transcripts within the human MHC region. These include 593 novel isoforms of knowndoi:10.4049/jimmunol.1701061 pmid:29311362 fatcat:wbqu7pmyj5hr7e7zrbtwmwx7le