Low hand grip strength (HGS) predicts several conditions, but its value outside of the older adult population is unclear. We sought to identify the most salient factors associated with HGS using a rich list of candidate variables while stratifying by age and sex. Methods: We used data from the initial visit from the Project Baseline Health Study (N=2502) which captured detailed demographic, occupational, social, lifestyle, and clinical data. We applied MI-LASSO using group methods to determine

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... ariables most associated with HGS out of 175 candidate variables. We performed analyses separately for sex and age (<65 vs. ≥65). Results: Race was associated with HGS to varying degrees across groups. Osteoporosis and osteopenia were negatively associated with HGS in female study participants. Immune cell counts were negatively associated with HGS for male participants ≥65 (neutrophils) and female participants (≥65, monocytes; <65, lymphocytes). Most findings were age and/or sex group-specific; few were common across all groups. Conclusions: Several of the variables associated with HGS in each group were novel, while others corroborate previous research. Our results support HGS as a useful indicator of a variety of clinical characteristics; however, its utility varies by age and sex.