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Reworking GWAS Data to Understand the Role of Nongenetic Factors in MS Etiopathogenesis
2020
Genes
Genome-wide association studies have identified more than 200 multiple sclerosis (MS)-associated loci across the human genome over the last decade, suggesting complexity in the disease etiology. This complexity poses at least two challenges: the definition of an etiological model including the impact of nongenetic factors, and the clinical translation of genomic data that may be drivers for new druggable targets. We reviewed studies dealing with single genes of interest, to understand how
doi:10.3390/genes11010097
pmid:31947683
pmcid:PMC7017269
fatcat:l62b4ntdn5cazpp3m23mvektji