Integrating phenotypic small-molecule profiling and human genetics: the next phase in drug discovery

Cory M. Johannessen, Paul A. Clemons, Bridget K. Wagner
2015 Trends in Genetics  
Over the past decade, tremendous progress in high-throughput small-molecule screening methods has facilitated the rapid expansion of phenotype-based data. Parallel advances in genomic characterization methods have complemented these efforts by providing a growing list of annotated cell line features. Together, these developments have paved the way for feature-based identification of novel, exploitable cellular dependencies, subsequently expanding our therapeutic toolkit in cancer and other
more » ... ses. Here, we provide an overview of the evolution of phenotypic small-molecule profiling and discuss the most significant and recent profiling and analytical efforts, their impact on the field, and their clinical ramifications. We additionally provide a perspective for future developments in phenotypic profiling efforts guided by genomic science.
doi:10.1016/j.tig.2014.11.002 pmid:25498789 pmcid:PMC4281276 fatcat:6j4mfhnhuvel3aukob6oz4wxii