Acute myocardial infarction is a severe cardiovascular pathology. Recent studies have demonstrated that its clinical course depends not only on the size of necrosis zone, but also on the local inflammation activity. In this study, the dynamics of various cytokines (INF-γ, IL-4, IL-6, IL-8, IL-10, IL-12, and TGF-β) in patients with different clinical course and outcome of acute myocardial infarction was investigated. It was shown that cytokine dynamics is similar to the dynamics of other

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... ammatory factors. Complicated clinical course of myocardial infarction is characterised by manifested cytokine reaction and delayed normalisation of cytokine levels. In fatal myocardial infarction, IL-6 and INF-γ cytokines are suppressed. The evaluation of cytokine reaction in myocardial infarction patients could be used for predicting the clinical course and outcome of the disease.