POPULATION DISTRIBUTION OF ALCOHOL DEHYDROGENASE CLASS I IN FRANCE: COMPARISON WITH OTHER POPULATIONS, AND DISTRIBUTION WITH RESPECT TO GENDER AND AGE

C. COUTELLE, P. J. WARD, P. QUATTROCCHI, B. FLEURY
1998 Alcohol and Alcoholism  
In Caucasians, a genetic polymorphism is known for some alcohol dehydrogenase (ADH) systems (/J and y). Knowledge of population frequencies of the ft and y hepatic isozyme variants in France is a prerequisite to understanding any role this genetic variation might play in determining the risk of alcohol-related diseases. For the present study, the ADH phenotypes of 115 French Caucasian control subjects, consisting of 64 men and 51 women, were studied. The )32 subunit was found to have a very low
more » ... to have a very low frequency. The relative frequencies of ADH y subunits observed in French Caucasians were found to be in good agreement with those already observed in other Caucasian populations. When gender and age were taken into account, a particular group corresponding to young men (age <50 years) was characterized by a manifest discordance with the comparable female population.
doi:10.1093/oxfordjournals.alcalc.a008375 pmid:9566481 fatcat:imaf5zjw7zaujm3uppvv7geubm