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Current Status of Therapeutics and Diagnosis of HCV: A Review

Saba Altaf, Department of Life Sciences, School of Science, University of Management and Technology, Lahore, Pakistan 54770, Aisha Tarar, Nabiha Naeem, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan, 53700, Department of Life Sciences, School of Science, University of Management and Technology, Lahore, Pakistan 54770
2019 BioScientific Review  

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Hepatitis C virus (HCV) causes a very common blood borne infection. According to a recent estimate, 3% of world population is infected with HCV. Acute infection develops into chronic infection that causes severe liver diseases. Major improvements in diagnosis and antiviral therapy play a crucial role in the management of chronic hepatitis infection. Better understanding of HCV life cycle introduced the development of direct acting antiviral drugs (DAA drugs). Currently, sovaldi or NS5B
more » ... is a major drug used for chronic HCV infection. New therapies are based on the combination of antiviral drugs and/or interferon free regimens. Many new DAA drugs, that are inhibitors of HCV genes, are under investigation. Serological and molecular techniques play a major role in the diagnosis and assessment of the treatment. Anti HCV detection by ELISA is an initial screening test, while nucleic acid tests (NATs) are confirmatory. Quantitative NATs have replaced the qualitative NATs. Developments in the field of diagnosis and treatment have replaced interferon based regimens with interferon free regimens.
doi:10.32350/bsr.0102.01 fatcat:pc2dcjg2jjd3dgkgatycrbxklm
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Saba Altaf, Department of Life Sciences, School of Science, University of Management and Technology, Lahore, Pakistan 54770, Aisha Tarar, Nabiha Naeem, Centre of Excellence in Molecular Biology, University of the Punjab, Lahore, Pakistan, 53700, Department of Life Sciences, School of Science, University of Management and Technology, Lahore, Pakistan 54770. "Current Status of Therapeutics and Diagnosis of HCV: A Review." BioScientific Review 01.02 (2019) 01-12