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Our previous results suggested that ruscogenin inhibited tumor necrosis factor α (TNF-α)-induced leukocyte adhesion, which correlated with its suppression of intercellular adhesion molecule-1 (ICAM-1) expression in endothelial cells. In the present studies, we further examined its effects on the main signaling pathways involved in upregulation of ICAM-1 induced by TNF-α in human umbilical vein endothelial cells (HUVECs). The results showed that ruscogenin significantly suppressed p65doi:10.1254/jphs.10076sc pmid:20724805 fatcat:w3rnapiss5a45puya2gr6n5jnm