Regression in development after seizure onset in tuberous sclerosis: a report of two cases

Chhitij Srivastava, Patrick Bolton
2013 American Journal of Autism  
We report two cases diagnosed with Tuberous Sclerosis Complex (TSC) that showed relatively late onset developmental regression with loss of skills following onset of epileptic spasms at around two years of age. Both the cases were reported to be developing normally before the regression. The regression in both children was characterised by a sudden and dramatic loss of intellectual abilities, social, communication and play skills and the emergence of autistic symptoms. The loss of skills in one
more » ... case temporarily improved following initial treatment with steroids, but recurred after seizures (including periods of status epilepticus) began again. In both cases, the loss of skills persisted after seizures were eventually controlled. At follow-up after 5 + years of age, one child had developed all the features of autism, whereas the child who had shown transient developmental improvement following treatment with steroids had developed a number of symptoms of autism, but not the full syndrome.
doi:10.7726/aja.2013.1001 fatcat:y5q5ociiuncezdeydpzs6oleai