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Genes & Development
The bacteriophage ?~ transcriptional activator protein cII is a DNA-binding protein that coordinately regulates transcription from phage promoters important for lysogenic growth. We have genetically and structurally characterized more than 80 different single amino acid substitutions in this 97-amino-acid protein. A subset of 25 of these variant proteins was utilized for detailed biochemical analysis, which allows us to define specific domains critical for sequence-selective DNA recognition,doi:10.1101/gad.2.2.184 pmid:2966093 fatcat:tkijjawnirep3oar3th6m4ro2m