Surface-enhanced infrared absorption of nucleic acids on gold substrate in FTIR reflectance mode

G. I. Dovbeshko, Vladimir I. Chegel, Nina Y. Gridina, O. P. Repnytska, I. V. Sekirin, Yuri M. Shirshov, Sergey V. Svechnikov, Volodymyr P. Kojemiako, Sergey A. Kostyukevych
2001 Selected Papers from the International Conference on Optoelectronic Information Technologies  
Data on surface enhanced infrared absorption (SEIRA) of nucleic acids deposited on the metal surface have been obtained in the experiment in FTIR reflectance mode. As metal surface, we used Au of 200-500 Å thickness on glass substrate. Roughness of Au was about 50 Å. In our experimental conditions, the enhancement factor of SEIRA was 3 to 5. We obtained different enhancement factors for different vibrations of nucleic acids. Application of this method to tumour nucleic acid gave a possibility
more » ... ave a possibility to reveal some structural peculiarities of their sugar-phosphate backbone and those after application of anti-cancer drugs.
doi:10.1117/12.429717 fatcat:isu4xbk72zepziaynk7kglhoby