Electroactive surfaces based on conducting polymers for controlling cell adhesion, signaling, and proliferation

Edwin W. H. Jager, Maria H. Bolin, Karl Svennersten, Xiangjun Wang, Agneta Richter-Dahlfors, Magnus Berggren
2009 TRANSDUCERS 2009 - 2009 International Solid-State Sensors, Actuators and Microsystems Conference  
We report on a variety of electroactive surfaces for the control of in vitro cell adhesion, proliferation, and stimulation. Planar cell culture substrates have been coated with the conducting polymer PEDOT and by switching the redox state, adhesion and proliferation of MDCK epithelial cells was controlled as well as stem cell seeding density. Electronically active 3D-scaffolds based on electrospun PET nano-fibers coated with PEDOT have been used as a substrate to culture SH-SY5Y neuroblastoma
more » ... Y5Y neuroblastoma cells and to induce Ca 2+ signaling. Finally, we report on micromechanical stimulation of cells using an electroactive topography surface based on micropattened polypyrrole.
doi:10.1109/sensor.2009.5285718 fatcat:ix2hw6666rfj7fx7gddokkvcsi