Efficacy and toxicity of mitoxantrone and oral etoposide in the treatment of hormone-refractory prostate cancer: pilot study

Rafael Kaliks, Camila Guerra, Auro Del Giglio
2010 Einstein (São Paulo)  
Objective: To evaluate the efficacy and toxicity of the association of mitoxantrone and oral etoposide. Methods: Twelve consecutive patients with metastatic hormone-refractory prostate cancer were treated with mitoxantrone and oral etoposide. Toxicity, response rate and response duration were assessed. Results: Partial response was observed in two patients (response duration of seven and four months) and one patient had stable disease (during four months). Mitoxantrone and oral Etoposide were
more » ... ll tolerated and did not affect tolerability to subsequent chemotherapy. Conclusion: Mitoxantrone and oral etoposide association is an active and well-tolerated regimen in hormone-refractory prostate cancer.
doi:10.1590/s1679-45082010ao1622 pmid:26760150 fatcat:v6xldizkxzcr7i6fa2gjf4jike