Acute Lymphoblastic Leukemia Associated with a t(l;l9)(q23;pl3) in an Adult

Hitoshi OHNO, Tetsurou INOUE, Takashi AKASAKA, Atsuko OKUMURA, Setsuko MIYANISHI, Isao OHASHI, Masahiko KIKUCHI, Masahiro MASUYA, Hiroyuki AMANO, Takanobu IMANAKA, Yoh-ichirou OHNO
1993 Internal medicine (Tokyo. 1992)  
A cytogenetic study ofa 38-year-old patient with acute lymphoblastic leukemia (ALL) revealed a t(l;19)(q23;pl3), which is a characteristic translocation of childhood ALL. The leukemic cells were positive for the CD10, CD19, HLA-DR, TdT and cytoplasmic ji-chain. Both of the immunoglobulin heavy chain gene loci were rearranged and the RNA-based polymerase chain reaction demonstrated the E2A/PBX1fusion transcript which is the result of the t(l;19). This finding suggests that the t(l;19) is
more » ... ed not only in childhood ALLbut also in adult ALL patients. (Internal Medicine 32: 584-587, 1993)
doi:10.2169/internalmedicine.32.584 fatcat:nfr4rjapmbfljhhub3i7g25vce