New paradigms for metabolic modeling of human cells

Adil Mardinoglu, Jens Nielsen
2015 Current Opinion in Biotechnology  
Highlights 16 We presented the timeline of generation and evaluation of global reconstructions of human 17 metabolism. 18 We reviewed the generation of the context specific GEMs through the use of human generic 19 GEMs. 20 We discussed the generation of multi-tissue GEMs in the context of whole-body metabolism. 21 We finally discussed the integration of GEMs with other biological networks. 22 23 24 25 Abstract 26 Abnormalities in cellular functions are associated with the progression of human
more » ... seases, 27 often resulting in metabolic reprogramming. GEnome-scale metabolic Models (GEMs) have 28 enabled studying global metabolic reprogramming in connection with disease development in 29 a systematic manner. Here we review recent work on reconstruction of GEMs for human 30
doi:10.1016/j.copbio.2014.12.013 pmid:25559199 fatcat:fagnmb2zsrdihfv6dlc43rccxa