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We present a detailed numerical study of the interaction between fast particles and large-scale magnetic perturbations and toroidal field ripple. In particular we focus our study on the losses of fast ions created by neutral beam injection (NBI) for an ASDEX Upgrade discharge with neoclassical tearing mode (NTM) activity. For these investigations, we use as input an equilibrium carefully reconstructed from experimental data. The magnetic field ripple is self-consistently included by adoi:10.1088/1367-2630/10/2/023017 fatcat:cy5zje6swjfbtetevda64inb5m