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Antiphospholipid syndrome (APS) is a multisystem disorder characterized by arterial and venous thromboses, pregnancy morbidity, and various neuropsychiatric manifestations. Cognitive dysfunction in APS has been poorly recognized. We examined for the first time, to our knowledge, the presence of cognitive dysfunction in patients with APS and its association with clinical, laboratory, and cerebral magnetic resonance imaging characteristics. Methods: Sixty patients (39 with primary APS and 21 withdoi:10.1001/archinte.166.20.2278 pmid:17101948 fatcat:f5cieyjiyraa7byaozfl56aw6q