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The comparison of relative gene orders between two genomes offers deep insights into functional correlations of genes and the evolutionary relationships between the corresponding organisms. Methods for gene order analyses often require prior knowledge of homologies between all genes of the genomic dataset. Since such information is hard to obtain, it is common to predict homologous groups based on sequence similarity. These hypothetical groups of homologous genes are called gene families.doi:10.1186/1471-2105-13-s19-s3 pmid:23281826 pmcid:PMC3526435 fatcat:ydnaay67w5bc7geypzikzhfbv4