As a result of the multicomponent condensation reaction between the thiophenylidenemalononitril and malononitriles with (S)-(-)-1-phenylethylamine new heterocyclic dihydropyridine derivative [(S)-(-)-6amino-2-imino-1-(1-phenylethyl)-4-(thiophen-2-yl)-1,2-dihydropyridine-3,5-dicarbonitrile] was synthesized. DMSO-d 6 solutions of the new compound have been investigated in the presence of βcyclodextrin by using the 2D DOSY method. As confirmed by our investigations, water molecules formed the

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... ned intermolecular hydrogen bond with the β-cyclodextrin and sample. Also, the hydrodynamic radius of new dihydropyridine derivative has been calculated.