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Sulfonylureas have represented the backbone of oral therapy in non-insulindependent diabetes mellitus for >30 yr. Despite this, our knowledge about the mode of actions of these agents is limited, and the use of them is far from rational. Sulfonylureas lower blood glucose concentrations primarily by stimulating insulin secretion. The evidence for clinically significant extrapancreatic effects is scanty. Therefore, the effect of sulfonylurea is limited to patients with preserved f$-cell function,doi:10.2337/diacare.15.6.737 pmid:1600834 fatcat:wmx3u4nu2jgzzkoespri452id4