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MiGut: a scalable in vitro platform for simulating the human gut microbiome - development, validation, and simulation of antibiotic induced dysbiosis
In vitro models of the human colon have been used extensively in developing understanding of the human gut microbiome and how internal and external factors affect the residing bacterial populations. Such models can be highly predictive of in vivo effects of antibiotics, and indeed more so than animal models. The complexity required by current in vitro models to closely mimic the physiology of the colon poses practical limits on their scalability. MiGut allows considerable expansion of modeldoi:10.1101/2022.09.02.506309 fatcat:2337w2pgibcwhcf3ewj5nccize