A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2017; you can also visit the original URL.
The file type is application/pdf
.
Genome Regulation by Long Noncoding RNAs
2012
Annual Review of Biochemistry
The central dogma of gene expression is that DNA is transcribed into messenger RNAs, which in turn serve as the template for protein synthesis. The discovery of extensive transcription of large RNA transcripts that do not code for proteins, termed long noncoding RNAs (lncRNAs), provides an important new perspective on the centrality of RNA in gene regulation. Here, we discuss genome-scale strategies to discover and characterize lncRNAs. An emerging theme from multiple model systems is that
doi:10.1146/annurev-biochem-051410-092902
pmid:22663078
pmcid:PMC3858397
fatcat:ktyi4pycbzdcjlb2uzuyaark3e