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Fibrinogen (FIBR) Binding Is Necessary For Incorporation Of 125I-Labeled Membrane Protein Into The Platelet Cytoskeleton
Thrombosis and Haemostasis
Platelets stimulated with ADP bind fibr specifically, and this ability correlates well with their ability to aggregate when they are shaken with ADP and fibr. Others found that platelets incubated with chymotrypsin (CT) bind and aggregate with fibr without stimulation by ADP; as with ADP-induced stimulation, these responses are inhibited by excess EDTA. Phillips et al. showed that thrombin activation produced a large Triton-insoluble cytoskeleton in the presence of either EDTA or CaCl2, butdoi:10.1055/s-0038-1652559 fatcat:pm2ikhat5jfrvmfymawfp5otwi