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Supplementary Figure 2 from SBE6: a novel long-range enhancer involved in driving sonic hedgehog expression in neural progenitor cells
The expression of genes with key roles in development is under very tight spatial and temporal control, mediated by enhancers. A classic example of this is the sonic hedgehog gene (Shh) that plays a pivotal role in the proliferation, differentiation and survival of neural progenitor cells both in vivo and in vitro. Shh expression in the brain is tightly controlled by several known enhancers that have been identified through genetic, genomic and functional assays. Using chromatin profilingdoi:10.6084/m9.figshare.4205904 fatcat:vbaglevlovhqzlk2evw3bqj4vy