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This review outlines the recent progress made in developing more accurate and efficient solutions to model electrostatics in systems comprised of bio-macromolecules and nano-objects, the last one referring to objects that do not have biological function themselves but nowadays are frequently used in biophysical and medical approaches in conjunction with bio-macromolecules. The problem of modeling macromolecular electrostatics is reviewed from two different angles: as a mathematical taskdoi:10.2478/mlbmb-2013-0002 pmid:24199185 pmcid:PMC3816640 fatcat:3v7q5ehr3faqpmkcokrgr5lhne