Adverse drug reactions (ADRs) are anxious unintended responses to drugs that occur at a dose usually used by humans. ADR is a significant problem with a considerable concern as it might cause a high rate of hospital admission. However, ADRs could be prevented by identifying, evaluating, and recording such reactions. Therefore, this study aimed to evaluate prescribers' knowledge, attitude, and practice (KAP) levels at tertiary care hospitals. Methods: This cross-sectional study was carried out

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... tertiary care hospitals. The study used a questionnaire to investigate the level of KAP among prescribers. In addition, the demographics, level of knowledge, attitude, and practice of prescribers were investigated. Results: This study involved 152 participants; only 44.1% were aware of drugs that have been banned due to ADRs, and 53.3% had reported ADRs before. The total KAP was high among only 32.9%. The level of KAP among prescribers was considerably associated with gender (P=0.0001), the previous reporting of ADRs (P=0.011), and the access to the ADR reporting system (P=0.016). Conclusion: There was a low level of knowledge, attitude, and practice of reporting ADRs among prescribers at a tertiary hospital. Keywords: ADRs, KAP, Prescribers, drugs