Experimental Infection of Young Specific Pathogen‐Free Cats withBartonella henselae

Lynn Guptill, Leonard Slater, Ching‐Ching Wu, Tsang‐Long Lin, Lawrence T. Glickman, David F. Welch, Harm HogenEsch
1997 Journal of Infectious Diseases  
Eighteen 12-week-old specific pathogen -free cats, blood culture -and serum antibody -negative for Bartonella henselae, were randomly allocated to groups and were intravenously inoculated with 10 10 (group 1), 10 8 (group 2), or 10 6 (group 3) B. henselae or with saline (group 4) or were not inoculated (group 5). Cats were humanely killed at 2, 4, 8, 16, and 32 weeks after inoculation. All B. henselae -inoculated cats were bacteremic by 2 weeks after infection. Bacteremia persisted until 32
more » ... sisted until 32 weeks after infection in 1 cat. Cats in groups 1 and 2 had fever (ú39.7ЊC) and partial anorexia by 2 weeks after infection that lasted 2 -7 days. All infected cats had Bartonella-specific IgM and IgG serum antibodies and lymphocyte blastogenic responses. Histopathologic lesions were observed in multiple organs of infected cats through 8 weeks after infection. Cats were readily infected with B. henselae by intravenous inoculation, developed histopathologic lesions that apparently resolved, and developed B and T lymphocyte responses to infection.
doi:10.1086/514026 pmid:9207369 fatcat:ngwy7crkrjhmnigzxo6wapvmbi