Population Pharmacokinetic And Exposure–Response Analyses Of Intravenous And Subcutaneous Rituximab In Patients With Chronic Lymphocytic Leukemia

Ekaterina Gibiansky, Leonid Gibiansky, Clarisse Chavanne, Nicolas Frey, Candice Jamois
2021 CPT: Pharmacometrics & Systems Pharmacology  
A subcutaneous formulation of the anti-CD20 antibody rituximab has been developed. Fixed-dose subcutaneous rituximab delivers non-inferior serum trough concentrations (Ctrough ), ensuring similar target saturation and comparable efficacy/safety to intravenous rituximab, but with simplified and shortened preparation and administration. We aimed to characterize the pharmacokinetic and exposure-response properties of subcutaneous rituximab. Data from two clinical trials were analyzed to describe
more » ... armacokinetics and pharmacodynamics in patients with chronic lymphocytic leukemia following intravenous and subcutaneous rituximab administration. Intravenous and subcutaneous rituximab were described by a linear two-compartment population pharmacokinetic model with time-dependent and time-independent clearances, and first-order subcutaneous absorption. Main covariates influencing exposure were body size and baseline white blood cell count. Occurrence of adverse events was not correlated with rituximab exposure. While greater and more sustainable B-cell depletion was observed with higher exposure, inherent limitations to the data (use of one dose level, time-dependent and target-impacted pharmacokinetics) prevented reliable assessment of exposure-response relationships.
doi:10.1002/psp4.12665 pmid:34110098 pmcid:PMC8376135 fatcat:o5ougchlurejtmuixzca2xyxkq