The Role of Circulating Biomarkers in Lung Cancer

Sayuri Herath, Habib Sadeghi Rad, Payar Radfar, Rahul Ladwa, Majid Warkiani, Ken O'Byrne, Arutha Kulasinghe
2022 Frontiers in Oncology  
Lung cancer is the leading cause of cancer morbidity and mortality worldwide and early diagnosis is crucial for the management and treatment of this disease. Non-invasive means of determining tumour information is an appealing diagnostic approach for lung cancers as often accessing and removing tumour tissue can be a limiting factor. In recent years, liquid biopsies have been developed to explore potential circulating tumour biomarkers which are considered reliable surrogates for understanding
more » ... umour biology in a non-invasive manner. Most common components assessed in liquid biopsy include circulating tumour cells (CTCs), cell-free DNA (cfDNA), circulating tumour DNA (ctDNA), microRNA and exosomes. This review explores the clinical use of circulating tumour biomarkers found in liquid biopsy for screening, early diagnosis and prognostication of lung cancer patients.
doi:10.3389/fonc.2021.801269 pmid:35127511 pmcid:PMC8813755 fatcat:hsil5ci44ngi3eo4vy34snoj7m