Evaluation of Intrapulmonary Shunt Alterations at Different Oxygen Concentrations and Oxygenation Parameters

Zerrin Demirtürk, Ecder Özenç, Sibel Buluç Bulğen
2015 Haseki Tıp Bülteni  
Abs tract Aim: The aim of the current study was to evaluate the relationship of intrapulmonary shunt with FiO 2 alterations in patients treated with mechanical ventilation in intensive care unit for extrapulmonary disorders. Also, we aimed to assess the role of correlation between shunt ratio and PaO 2 /FiO 2 , PaO 2 /PAO 2 , P(A-a) O 2 values in determining the treatment strategies. Methods: Twenty patients between ages of 19 and 75 years, requiring mechanical ventilation were enrolled into
more » ... re enrolled into the study. We excluded two patients due to congestive heart failure and two patients due to acute respiratory distress syndrome (ARDS). Shunt fraction, P(A-a)O 2 , PaO 2 /FiO 2 , PaO 2 /PAO 2 values were calculated at each FiO 2 level for each patient. Results: The lowest median shunt value was measured at FiO 2 : 0.3 There was a significant correlation between shunt values at FiO 2 0.5 and 0.7 (r=0.850). The highest mean value of P(A-a)O 2 was measured at FiO 2 : 1 (382.91±106.46), and the lowest value of P(A-a)O 2 was measured at FiO 2 : 0.21 (38.64±16.97). PaO 2 /FiO 2 and PaO 2 /PAO 2 ratios measured at FiO 2 : 0.3 and 0.5 were found to be statistically significant. Conclusion: In this study, we have shown increased shunt fraction at FiO 2 : 1 level. Different oxygenation indices and shunt measurements give us important and useful knowledge about the patients' current condition. (The Me di cal Bul le tin of Ha se ki 2015; 53:124-9)
doi:10.4274/haseki.1932 fatcat:dbjtox4q6ff37nmu6evrlsppfy