The aim of this communication is to present our protocol of management and treatment and to discuss our experience in the management of MRONJ patient at the Division of Maxillofacial Surgery at Novara Hospital in the last twelve years. A revision of all patients affected by MRONJ that were diagnosed between January 2009 and December 2020 was performed. On the whole, 109 patients with a mean age of 70 years were included: 75 patients had mandibular ONJ, whereas 27 maxillary ONJ and the remaining

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... 7 patients mandibular and maxillary ONJ. 54% of patients was classified as Stage 1, 30% as Stage 2, and 16% as Stage 3. In 87 cases, patients underwent, in addition to medical therapy, surgical interventions of curettage, sequestrectomy, or bone resection; the remaining 22 patients were just administered medical therapy. Advanced Stage MRONJ can be efficiently managed by surgery combined with medical therapy.