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Mfn2 Affects Embryo Development via Mitochondrial Dysfunction and Apoptosis
2015
PLoS ONE
Growth factors, energy sources, and mitochondrial function strongly affect embryo growth and development in vitro. The biological role and prospective significance of the mitofusin gene Mfn2 in the development of preimplantation embryos remain poorly understood. Our goal is to profile the role of Mfn2 in mouse embryos and determine the underlying mechanism of Mfn2 function in embryo development. Methods We transfected Mfn2-siRNA into 2-cell fertilized eggs and then examined the expression of
doi:10.1371/journal.pone.0125680
pmid:25978725
pmcid:PMC4433325
fatcat:ehm5rds5jvaxhcv3rbutrfpcvm