A dual optical and nuclear imaging reagent for peptide labelling via disulfide bridging

Sally A. Fletcher, Pak Kwan Brian Sin, Muriel Nobles, Erik Årstad, Andrew Tinker, James R. Baker
2015 Organic and biomolecular chemistry  
We report a concise approach to a multimodal imaging reagent for peptide labelling via disulfide bridging. The reagent is constructed using a one pot, three component, [3 + 2] cycloaddition of a fluorescent azide with a dithiomaleimide-alkyne, with concomitant incorporation of 125I.
doi:10.1039/c5ob01468a pmid:26299430 fatcat:flql4w5voze7hbanylaof37j6a