A copy of this work was available on the public web and has been preserved in the Wayback Machine. The capture dates from 2020; you can also visit the original URL.
The file type is application/pdf
.
Dynamic Covalent Identification of an Efficient Heparin Ligand
2018
Angewandte Chemie
Despite heparin being the most widely used macromolecular drug, the design of small-molecule ligands to modulate its effects has been hampered by the structural properties of this polyanionic polysaccharide. In this work we used a dynamic covalent selection approach to identify a new ligand for heparin, assembled from extremely simple building blocks. The amplified molecule strongly binds to heparin (KD in the low M range, ITC) by a combination of electrostatic, hydrogen bonding and CH-π
doi:10.1002/ange.201806770
fatcat:e3biy76airewnk45cfm5dfknfy