Background: The kidneys are important organs in the human body that have many functions. Kidney function is divided into several processes, namely filtration, reabsorption and secretion of substances in the body. Nephron which is the smallest kidney functional unit that is responsible for accommodating all functions in the kidney. One of the functions of the kidneys is secretion, the secretions in the kidneys work by removing electrolytes and other substances that are no longer needed by the

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... y through urine. When the function of the kidney nephrons is disturbed, it can result in an electrolyte imbalance (K), a buildup of waste from substances that are not needed by the body (creatinine). The objective of this research was to examine the relationship between electrolytes (K) serum, urine and creatinine in patients with CKD.Methods: The research was conducted by observational, anamnesis, and sampling of CKD patients at Dr. Kariadi Semarang during the period March-May 2020.Results: The results of the multivariate linear regression test showed that creatinine had a moderate significant positive effect at p = 0.024 and r = 0.412 on serum K. Meanwhile, from multivariate linear regression, it was found that creatinine had a moderate negative effect at p = 0.027 and r = -0.456 on urine K.Conclusions and suggestions: The findings proved the relationship between creatinine levels and serum and urine potassium levels in patients with CKD. Serum and urine electrolytes can be used as an parameter for CKD management.