Current practice in the use of MEGA-PRESS spectroscopy for the detection of GABA

Paul G. Mullins, David J. McGonigle, Ruth L. O'Gorman, Nicolaas A.J. Puts, Rishma Vidyasagar, C. John Evans, Richard A.E. Edden
2014 NeuroImage  
a r t i c l e i n f o Available online xxxx There is increasing interest in the use of edited proton magnetic resonance spectroscopy for the detection of GABA in the human brain. At a recent meeting held at Cardiff University, a number of spectroscopy groups met to discuss the acquisition, analysis and interpretation of GABA-edited MR spectra. This paper aims to set out the issues discussed at this meeting, reporting areas of consensus around parameters and procedures in the field and
more » ... ng those areas where differences remain. It is hoped that this paper can fulfill two needs, providing a summary of the current 'state-of-the-art' in the field of GABA-edited MRS at 3 T using MEGA-PRESS and a basic guide to help researchers new to the field to avoid some of the pitfalls inherent in the acquisition and processing of edited MRS for GABA.
doi:10.1016/j.neuroimage.2012.12.004 pmid:23246994 pmcid:PMC3825742 fatcat:zbtoo4yixjcevonkaz54zvetue