High Interobserver Agreement in the Subjective Classification of 5‐Aminolevulinic Acid Fluorescence Levels in Newly Diagnosed Glioblastomas

Mario Mischkulnig, Barbara Kiesel, Martin Borkovec, Lisa I. Wadiura, Dimitri Benner, Arthur Hosmann, Shawn Hervey‐Jumper, Engelbert Knosp, Karl Roessler, Mitchel S. Berger, Georg Widhalm
2020 Lasers in Surgery and Medicine  
Fluorescence-guided resection of glioblastomas (GBM) using 5-aminolevulinic acid (5-ALA) improves intraoperative tumor visualization and is thus widely used nowadays. During resection, different fluorescence levels can usually be distinguished within the same tumor. Recently, we demonstrated that strong, vague, and no fluorescence correspond to distinct histopathological characteristics in newly diagnosed GBM. However, the qualitative fluorescence classification by the neurosurgeon is
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doi:10.1002/lsm.23228 pmid:32147864 fatcat:qhvdxlavqfhx5isvsomlg25tam