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Targeting the ERK pathway for the treatment of Cushing's disease
2016
OncoTarget
We recently demonstrated that the orphan nuclear receptor testicular receptor 4 (TR4) is a potent regulator of corticotroph tumor growth and hormone secretion. The Ras/Raf/MEK/ERK pathway is commonly overactivated in human tumors and we have demonstrated that corticotroph tumor TR4 is activated by ERK1/2-mediated phosphorylation. We evaluated effects of MEK-162, a selective, non-ATP-competitive allosteric inhibitor of MEK1/2, on murine and human in vitro and in vivo corticotroph tumor
doi:10.18632/oncotarget.12381
pmid:27708250
pmcid:PMC5342466
fatcat:foupp46mgvgp7k6lbzv55rwei4