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The effect of tea brew on the excretion and tisue distribution of (~-m e t h~l -~~C ) caffeine was investigated. Following oral administration of 14 (I-methyl-C) caffeine t o male and female rats, the radioactivity was excreted (approx. 62% and 70% respectively) mainly in the urine, the greater part of t h e excretion occuring during 12 -24h period; small amounts (approx. 7% and 9% respectively) were found in the urine. In contrast, the oral administration of ( l -m e t l~~l -~~~) caffeine withdoi:10.4038/jnsfsr.v13i1.8347 fatcat:rbbq4u7mknhmljubc2tqk2mnoi