HGTree: database of horizontally transferred genes determined by tree reconciliation

Hyeonsoo Jeong, Samsun Sung, Taehyung Kwon, Minseok Seo, Kelsey Caetano-Anollés, Sang Ho Choi, Seoae Cho, Arshan Nasir, Heebal Kim
2015 Nucleic Acids Research  
The HGTree database provides putative genomewide horizontal gene transfer (HGT) information for 2472 completely sequenced prokaryotic genomes. This task is accomplished by reconstructing approximate maximum likelihood phylogenetic trees for each orthologous gene and corresponding 16S rRNA reference species sets and then reconciling the two trees under parsimony framework. The tree reconciliation method is generally considered to be a reliable way to detect HGT events but its practical use has
more » ... mained limited because the method is computationally intensive and conceptually challenging. In this regard, HGTree (http://hgtree.snu.ac.kr) represents a useful addition to the biological community and enables quick and easy retrieval of information for HGT-acquired genes to better understand microbial taxonomy and evolution. The database is freely available and can be easily scaled and updated to keep pace with the rapid rise in genomic information.
doi:10.1093/nar/gkv1245 pmid:26578597 pmcid:PMC4702880 fatcat:woxhoski2ffubleeyt7bzrxw6m