Protein Recruitment through Indirect Mechanochemical Interactions

Andriy Goychuk, Erwin Frey
2019 Physical Review Letters  
Some of the key proteins essential for important cellular processes are capable of recruiting other proteins from the cytosol to phospholipid membranes. The physical basis for this cooperativity of binding is, surprisingly, still unclear. Here, we suggest a general feedback mechanism that explains cooperativity through mechanochemical coupling mediated by the mechanical properties of phospholipid membranes. Our theory predicts that protein recruitment, and therefore also protein pattern
more » ... n, involves membrane deformation, and is strongly affected by membrane composition.
doi:10.1103/physrevlett.123.178101 fatcat:4s2m3rtkybcf3dwvf57vagbyom