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Hybrid optimization of preparative chromatography for a ternary monoclonal antibody mixture
2019
Biotechnology progress (Print)
In the purification of monoclonal antibodies, ion-exchange chromatography is typically used among the polishing steps to reduce the amount of product-related impurities such as aggregates and fragments, whilst simultaneously reducing HCP, residual Protein A and potential toxins and viruses. When the product-related impurities are difficult to separate from the products, the optimization of these chromatographic steps can be complex and laborious. In this paper, we optimize the polishing
doi:10.1002/btpr.2849
pmid:31121081
fatcat:mbf7rclasrhf5futz22nfgstku