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The purpose of this study was to investigate the effects of soluble products of activated lymphocytes and macrophages on mouse blastocyst attachment and trophoblast outgrowth in vitro, Hatched blastocysts were incubated with medium alone, supematant fluids from mixed lymphocyte cultures (MLC), and with individual human and murine lymphokines and monokines in flbronectin-coated wells. Cultures were assessed at 24, 48, and 72 h for blastocyst attachment and trophoblast outgrowth. Both human anddoi:10.1095/biolreprod44.1.69 pmid:2015353 fatcat:h6bgp4wimneb7c2cjn6chyl2ni