Purpose: To evaluate the choroidal thickness (CT) in patients with Multiple Sclerosis (MS) using enhanced depth imaging optical coherence tomography (EDI-OCT) and comparing it with healthy subjects. Material/Methods: Sixty-four eyes of 32 patients with MS (22 women, 10 men, mean age: 37.5 ± 8.21 years) were enrolled in this study. Their choroidal thickness was measured using EDI-OCT, and compared with healthy subjects. CT was measured at fovea and at four extrafoveal points. Results: The mean

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... bfoveal choroidal thickness was 327.01 ± 64.60 µm in MS patients and 365.3 ± 99.14 µm in controls ( p=0.019 ). Significant differences were found at points temporal 500 µm, temporal 1000 µm and nasal 500 µm to the fovea between patients and control group ( p=0.018, 0.003 and 0.03, respectively). Conclusions: Patients with MS had thinner choroids when compared to normal subjects. The decrease in mean choroidal thickness in MS patients compared to controls may be related to vascular dysregulation or inflammatory pathology of MS. Further prospective studies are needed to evaluate the choroidal thickness in MS patients.