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Rare variants (RVs) genetic association studies enable researchers to uncover the vari- ation in phenotypic traits left unexplained by common variation. Traditional single-variant analysis lacks power; thus, researchers have developed various methods to aggregate the effects of RVs across genomic regions to study their collective impact. Some existing methods utilize a static delineation of genomic regions, often resulting in suboptimal effect aggregation, as neutral subregions within the testdoi:10.1101/2022.12.01.518706 fatcat:ucfuzn5hbzg3tiupwwtk2hisiq