There is a paucity of data on the burden of obesity among primary Health care professional nurses in Eastern Cape Province of South Africa. This study examines the prevalence and determinants of overweight and obesity among Primary Healthcare Professional nurses in Eastern Cape Province of South Africa. This workplace cross-sectional study was conducted among 203 Primary Health Care Professional nurses selected conveniently across 41 primary healthcare facilities in Eastern Cape, South Africa

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... llowing a the WHO STEPwise approach and using the WHO STEPwise questionnaire for data collection. Data were expressed as mean, counts and proportions, as appropriate. We compared percentages using chi-square test. Descriptive and inferential statistics were conducted. Seventy six percent of the nurses were obese and 18% were overweight. Age, gender, marital status, duration of practice, alcohol use and smoking were significantly associated with obesity. Only age >30 years and not using alcohol were independent predictors of obesity, after adjusting for confounders. We found a high prevalence of obesity among primary healthcare professional nurses in this setting. This constitute future risk for an increased prevalence of chronic diseases among the healthcare workforce in this setting. There is a need for measures to promote healthy lifestyle behaviours and weight management among nurses in this setting.