Effects of Thyrotoxicosis on Mitochondrial Enzymes of Rat Soleus

J. Courtright, R. Fitts
1979 Hormone and Metabolic Research  
Cytochrome oxidase, glycerol-3-phosphate dehydrogenase, and succinate dehydrogenase were measured in mitochondrial fractions obtained from rat soleus muscle of control and 8 week T 3 + T 4 treated animals. Under these conditions of prolonged treatment, there is a five-fold increase in the specific activities of both cytochrome oxidase and glycerole-3-phosphate dehydrogenase. Significant increases in total cellular mitochondrial content and enzyme activities were observed in T 3 + T 4 treateq
more » ... mals as compared to controls. These results indicate that thyrotoxicosis can induce selective changes in mitochondrial enzymes in slow twitch red (Type I) muscle fibers
doi:10.1055/s-0028-1092729 pmid:222661 fatcat:lfszmytbq5bmrellt76mbq3vii