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Evidence for the Covalent Binding of SHAP, Heavy Chains of Inter-α-Trypsin Inhibitor, to Hyaluronan
Journal of Biological Chemistry
We previously showed that serum-derived 85-kDa proteins (SHAPs, serum-derived hyaluronan associated proteins) are firmly bound to hyaluronan (HA) synthesized by cultured fibroblasts. SHAPs were then identified to be the heavy chains of inter-␣-trypsin inhibitor (ITI) (Huang, L., Yoneda, M., and Kimata, K. (1993) J. Biol. Chem. 268, 26725-26730). In this study, the SHAP⅐HA complex was isolated from pathological synovial fluid from human arthritis patients. The SHAP⅐HA complex was digested withdoi:10.1074/jbc.270.44.26657 pmid:7592891 fatcat:py2b4h2x7nbipfocf5dnkowo2q